Endocrine Abstracts

Background: Hypothyroidism affects cardiac function, leading to cardiomyopathy, pericarditis, lower left ventricular performance, etc. The present study investigates different parameters (clinical, hormonal, biochemical, echocardiographic) in overt primary hypothyroidism (OPHypo) and overt central hypothyroidism (OCHypo).Material and methods: The study included 33 untreated patients with OCHypo (5 with empty sella, 3 with idiopathic hypopituitarism, 7 wi...

Background: Primary and secondary hyperparathyroidism (HP) are associated with increased risk for cardiovascular complications and high mortality. Risk factors correlated with hypertension in HP are hyperlipidemia, glucose intolerance, insulin resistance, vitamin D deficiency, etc. The aim of the study was to assess the incidence of cardiovascular complications in HP.Material and methods: The study included 45 patients (15 men, 30 women), with a mean age...

Sheehan’s syndrome represents a rare cause of pituitary insufficiency, produced by an ischemic pituitary necrosis due to a severe haemorrhage at deliverance. Epidemiologic data indicate that, nowadays, this disease is quite rare in developed country.Aim: To determine and evaluate the clinical and hormonal characteristics of cases with Sheehan’s syndrome diagnosed and follow-up in our Clinic, during the last ten years.Subj...

Introduction: Papillary thyroid carcinoma can be found very rarely in a thyroglossal duct cyst (TDC) (1%), this cancer variant being the most common type. Although, most of the TDC develop in the midline of the thyroglossal duct (~70%), some cysts occur off midline, within 2 cm of the midline.Case presentation: The female patient of 34-year-old presented at the Maxillofacial Surgery Department in October 2014, with a right submandibular painless neck mas...

Real-time shear wave ultrasound elastography (SWE) is a new technique, which evaluates elasticity and stiffness of the different structure.Aim: To determine the values of the elasticity index (EI) measured by SWE in parathyroid gland adenomas and to compare with those of normal thyroid tissue.Subjects and methods: We studied 50 cases (F/M=42/8), ten with primary or tertiary hyperparathyroidism, diagnosed by specific tests, and 40 h...

Background: Thyroid incidentalomas are reported with increasing incidence in the last decades. The rate of malignancy in these nodules may reach 9% or higher, depending on the patients selection.Material and methods: A retrospective study was done on 429 patients with nodular goiter (issued from an iodine-replete area), admitted in the Clinic of Endocrinology, Timisoara, Romania, from January 2011 to December 2013.Results: The prev...

Introduction: Acromegaly is a rare disease caused by excess production of growth hormone (GH) and is associated with multiple complications. The prevalence of associated complications and the mortality rate are associated with the duration of exposure to elevated GH levels, early diagnosis being imperative. Diagnosis of acromegaly is most frequently late, after several years of evolution, with the development of cardiovascular, respiratory, metabolic complications. The presenc...

Introduction: Gigantism represents a rare pathology in children, characterized by growth hormone (GH) excess, before epiphyseal fusion. It associates significant morbidity and decreased life expectancy, in lack of appropriate treatment.Case presentation: O.D., a male patient, 16 years old now, has been followed in our clinic since 2016, being diagnosed with gigantism in Bega Pediatric Clinic, at the age of 12 years 9 months. In 2014, the patient presente...

Introduction: Acromegaly is a debilitating, indolent disease that develops over several years due to extended exposure to elevated growth hormone (GH) levels. It is most commonly caused by somatotropinomas. It represents a rare pathology with an incidence of 3–14 cases per 1 million inhabitants and a prevalence of 40 to 90 cases per 1 million inhabitants. Pituitary adenomas respresent a challenging disease in young patients. Transphenoidal surgery is the best therapeutic...

Background: Acromegaly is a chronic rare disease induced by persistent hypersecretion of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) in adult patients. Several studies have associated acromegaly with an increased risk for developing different benign or malignant tumors.Case presentation: A 33-year old female patient was diagnosed with acromegaly due to a large pituitary macroadenoma, in 2009. In the same period, she was also diagnosed wi...